It's the best way to start your visit as Times Square is situated in the center.
Another option is to book a free walking tour and get to know the neghbourhood.
On the way through the entire area of lower Manhattan:
– Battery Park,
– Financial District,
– Tribeca, Chinatown,
– Little Italy (eat a real pizza!)
– Soho, etc.
New York is not only famous for its skyscrapers but also for shopping. One of the best outlets to buy all year round (and the next) is the Woodbury Common.